Three cases of acute fatty liver of pregnancy: Postpartum clinical course depends on interval between onset of symptoms and termination of pregnancy

Abstract

We report our experience with three cases of acute fatty liver of pregnancy. Case 1 complained of hydrodipsia 4 days before delivery. Case 2 presented with nausea, vomiting and dizziness 6 days before delivery. Case 3 developed loss of appetite and general fatigue with jaundice 10 days before delivery. They underwent termination of pregnancy after diagnosis was made. Case 3 still developed hepatic encephalopathy, and finally she required liver transplantation. We hypothesise that the interval between the onset of symptoms and termination of pregnancy is an important factor for acuity of the disorder and patient morbidity or mortality.

Keywords:

• Acute fatty liver of pregnancy
• plasma exchange
• liver transplantation

Declaration of interest: The authors report no conflicts of interest. The authors alone are responsible for the content and writing of the paper.