Characterization of three small supernumerary marker chromosomes (sSMC) in humans

Jian OuCenter for Reproduction and Genetics, Nanjing Medical University Affiliated Suzhou Hospital, Suzhou Municipal Hospital, Jiangsu, China

Wei WangCenter for Reproduction and Genetics, Nanjing Medical University Affiliated Suzhou Hospital, Suzhou Municipal Hospital, Jiangsu, China

Thomas LiehrJena University Hospital, Friedrich Schiller University, Institute of Human Genetics, Kollegiengasse 10, Jena, Germany

Elisabeth KleinJena University Hospital, Friedrich Schiller University, Institute of Human Genetics, Kollegiengasse 10, Jena, Germany

Ahmed B. HamidJena University Hospital, Friedrich Schiller University, Institute of Human Genetics, Kollegiengasse 10, Jena, Germany

Fuxin WangCenter for Reproduction and Genetics, Nanjing Medical University Affiliated Suzhou Hospital, Suzhou Municipal Hospital, Jiangsu, China

Chengying DuanCenter for Reproduction and Genetics, Nanjing Medical University Affiliated Suzhou Hospital, Suzhou Municipal Hospital, Jiangsu, China

Hong LiCenter for Reproduction and Genetics, Nanjing Medical University Affiliated Suzhou Hospital, Suzhou Municipal Hospital, Jiangsu, China

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Abstract

In the present study, three prenatally detected small supernumerary marker chromosomes (sSMC) were identified by banding cytogenetics and characterized in detail by molecular cytogenetics. In one case an sSMC(10) leading to a pericentric partial trisomy and in two cases heterochromatic sSMC derived from chromosome 22 were characterized. Outcomes were reportedly normal for two of the three cases for whom this information was known.

Keywords::

Declaration of Interest: The authors report no conflicts of interest. The authors alone are responsible for the content and writing of the paper.

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Characterization of three small supernumerary marker chromosomes (sSMC) in humans

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Characterization of three small supernumerary marker chromosomes (sSMC) in humans

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