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Short Report

Congenital pulmonary malformations: metabolomic profile of lung phenotype in infants

Gloria PelizzoDepartment of the Mother and Child Health, Pediatric Surgery Unit, IRCCS Policlinico San Matteo Foundation Pavia and University of Pavia, Pavia, Italy, Correspondence[email protected]

Maria Chiara MimmiDepartment of Medical and Biological Sciences, University of Udine, Udine, Italy,

Maurizio BallicoDepartment of Medical and Biological Sciences, University of Udine, Udine, Italy,

Mario MarottaCincinnati Fetal Center, Pediatric Surgery Division, CCHMC, Cincinnati, OH, USA, ;Fetal Surgery Program, Congenital Malformations Research Group, Research Institute of Hospital Universitari Vall d’Hebron, Edifici Infantil, Barcelona, Spain,

Ilaria GoruppiDepartment of the Mother and Child Health, Pediatric Surgery Unit, IRCCS Policlinico San Matteo Foundation Pavia and University of Pavia, Pavia, Italy,

Jose Louis PeiroCincinnati Fetal Center, Pediatric Surgery Division, CCHMC, Cincinnati, OH, USA, ;Fetal Surgery Program, Congenital Malformations Research Group, Research Institute of Hospital Universitari Vall d’Hebron, Edifici Infantil, Barcelona, Spain,

Elisa ZambaitiDepartment of the Mother and Child Health, Pediatric Surgery Unit, IRCCS Policlinico San Matteo Foundation Pavia and University of Pavia, Pavia, Italy,

Federico CostanzoDepartment of the Mother and Child Health, Pediatric Surgery Unit, IRCCS Policlinico San Matteo Foundation Pavia and University of Pavia, Pavia, Italy,

Erika AndreattaDepartment of the Mother and Child Health, Pediatric Surgery Unit, IRCCS Policlinico San Matteo Foundation Pavia and University of Pavia, Pavia, Italy,

Elena ToninDepartment of the Mother and Child Health, Pediatric Surgery Unit, IRCCS Policlinico San Matteo Foundation Pavia and University of Pavia, Pavia, Italy,

Valeria CalcaterraDepartment of the Mother and Child Health, Pediatric Unit, IRCCS Policlinico San Matteo Foundation Pavia, Pavia, Italy, and ;Department of Internal Medicine University of Pavia, Pavia, Italy

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Abstract

Background: The main hydrosoluble metabolites in three different human congenital pulmonary malformations are described by nuclear magnetic resonance (NMR) spectroscopy.

Methods: Bronchogenic cyst (BC), congenital lobar emphysema (CLE) and intrapulmonary sequestration (IPS), were analyzed with respect to a control sample. The extracted metabolites were submitted to high-resolution ¹H NMR-spectroscopy.

Results: Congenital lung malformations showed free choline, phosphocoline and myoinositol high levels. IPS and CLE were found increased in lactic acid/glucose ratio. Lactic acid and glucose values resulted to be more elevated in control sample.

Conclusions: Congenital lung lesions showed different metabolomic profiles useful for early diagnosis.

Keywords

Acknowledgements

We wish to acknowledge the “Associazione Bambini con la CCAM” for supporting research in our Pediatric Surgery Unit.

Declaration of interest

There are no conflicts of interest regarding the publication of this article.

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Congenital pulmonary malformations: metabolomic profile of lung phenotype in infants

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Congenital pulmonary malformations: metabolomic profile of lung phenotype in infants

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