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Abstract
Objective: The main aim of this study was to investigate the first trimester maternal serum secreted frizzle-related protein-5 (Sfrp-5) levels and to evaluate the predictive value on the subsequently developed gestational diabetes mellitus (GDM).
Methods: A total of 40 pregnant women who subsequently developed GDM and 44 age- and pre-pregnancy BMI-matched healthy pregnant women were enrolled in this prospective case-control study. First trimester serum Sfrp-5 levels were evaluated to determine if there is an association with the onset of GDM, by using logistic regression analysis.
Results: Decreased first trimester serum Sfrp-5 levels (OR = 14.332, 95%CI: 4.166–49.301, p < 0.001) were found to be significantly associated with the increased risk of GDM. There were no statistically significant differences in serum Sfrp-5 levels between the diet- and insulin-treated GDM groups and also serum Sfrp-5 levels were not found to be predictive for adverse perinatal outcomes (p > 0.05).
Conclusions: Decreased first trimester serum Sfrp-5 levels are significantly associated with the increased risk of GDM.
Declaration of interest
The authors report no conflicts of interest. The authors alone are responsible for the content and writing of this article.