Cytomegalovirus non-primary infection during pregnancy. Can serology help with diagnosis?

O. PiconeService de Gynécologie-Obstétrique et Médecine de la Reproduction, Hôpital Foch, Suresnes, France, ;Collège Français d’échographie Foetale (CFEF), Chateaubriant, France, ;EA2493, UFR des Sciences de la Santé Simone Veil, UVSQ, Montigny le Bretonneux, France,

L. Grangeot-KerosAP-HP, Hôpital Paul Brousse, Groupe Hospitalier Universitaire Paris-Sud, Virologie, WHO Rubella NRL, National Reference Laboratory for Maternofetal Rubella Infections, Univ Paris-Sud, INSERM U1193, Villejuif, France,

Mv SenatService de Gynécologie-Obstétrique, Hôpital Kremlin Bicêtre (AP-HP), Université Paris Sud, Bicetre, France, and

F. FuchsService de Gynécologie-Obstétrique, Hôpital Kremlin Bicêtre (AP-HP), Université Paris Sud, Bicetre, France, and

E. BouthryAP-HP, Hôpital Paul Brousse, Groupe Hospitalier Universitaire Paris-Sud, Virologie, WHO Rubella NRL, National Reference Laboratory for Maternofetal Rubella Infections, Univ Paris-Sud, INSERM U1193, Villejuif, France,

Jm AyoubiService de Gynécologie-Obstétrique et Médecine de la Reproduction, Hôpital Foch, Suresnes, France, ;EA2493, UFR des Sciences de la Santé Simone Veil, UVSQ, Montigny le Bretonneux, France,

A. BenachiService de Gynécologie-Obstétrique, Hôpital Antoine Béclère (AP-HP), Université Paris Sud, Clamart, France

C. Vauloup-FellousAP-HP, Hôpital Paul Brousse, Groupe Hospitalier Universitaire Paris-Sud, Virologie, WHO Rubella NRL, National Reference Laboratory for Maternofetal Rubella Infections, Univ Paris-Sud, INSERM U1193, Villejuif, France, Correspondence[email protected]

show all

Abstract

Diagnosis of cytomegalovirus (CMV) primary infection is reliable, but diagnosis of CMV non-primary infection (NPI) is questionable. Our aim is to highlight the difficulties met in diagnosis of CMV NPI. We illustrate that in proven cases of CMV NPI, very different serologic and molecular patterns may be observed and that routine serologic testing may fail to help with diagnosis. These results point out that many data available in literature concerning the prevalence of NPI, materno-fetal transmission rates and consequences of NPI may be wrong. We need to know how frequently they occur, are transmitted and cause fetal damages. Diagnosis of NPI must be improved, along with our understanding of the mechanisms leading to intrauterine CMV transmission and congenital infection in babies born to women with preexisting immunity.

Keywords

Declaration of interest

The authors report no conflicts of interest. The authors alone are responsible for the content and writing of this article.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Cytomegalovirus non-primary infection during pregnancy. Can serology help with diagnosis?

Information for

Open access

Opportunities

Help and information

Cytomegalovirus non-primary infection during pregnancy. Can serology help with diagnosis?

Abstract

Declaration of interest

Reprints and Corporate Permissions

Academic Permissions

Related research

To cite this article:

Download citation

Information for

Open access

Opportunities

Help and information

Keep up to date

Your download is now in progress and you may close this window

Login or register to access this feature