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Original Article

The effects of high stimulus rate on the electrocochleogram in normal-hearing subjects: El efecto de una alta tasa de estimulacion en la electrococleografia de sujetos normoyentes

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Pages 509-517 | Received 18 Jun 2001, Accepted 10 Nov 2001, Published online: 07 Jul 2009
 

Abstract

The use of high stimulus rates has the potential to improve the electrocochleogram's (ECochG) sensitivity and specificity in endolymphatic hydrops and Menière's disease, but is currently hindered by the absence of an acceptable normative database. In response, this study recorded click-evoked ECochG tracings from 51 normal-hearing subjects (102 ears), between 18 and 60 years of age, at 7.1, 51.1, 101.1 and 151.1 clicks/s using a tympanic membrane electrode. As stimulus rate increased, various statistically significant (p < 0.05) changes were observed. In general, summating potential (SP) latency and amplitude and action potential (AP) latency increased, SP/AP amplitude ratio and waveform width increased but then plateaued, and AP amplitude fluctuated. While providing the largest contribution to a high-stimulus-rate ECochG normative database published to date, potential clinical limitations were identified and a possible solution proposed.

Sumario: La utilización de altas tasas de estimulación tiene el potencial de mejorar la sensibilidad y la especificidad de la electrococleografia (ECochG) en el hidrops endolinfático y en la enfermedad de Meniére, pero está actualmente interferida por la ausencia de una base de datos normativa aceptable. Por ello, en este estudio se registraron trazos de EcochG evocados por clicks, en 51 sujetos normo-oyentes (102 oidos), entre los 18 y los 60 años de edad, con una tasa de 7.1, 51.1, 101.1 y 151.1 clicks/segundo, utilizando un electrodo para-timpánico. Conforme la tasa de estimulación aumentó, la amplitud y la latencia de los potentiates de sumación (SP) se incrementó levemente, la amplitud de los potenciales de acción (AP) fluctuó, y la latencia de los AP, así como la tasa de amplitud de los SP/AP y el ancho de banda aumentaron. Además de aportar la mayor contributión publicada hasta la fecha sobre una base de datos normativa para ECochG con alta tasa de estimulación, se identificaron limitaciones clinicas potenciales y se propusieron posibles soluciones.

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