Dimethyl Sulfoxide–Sodium Bicarbonate Infusion for Palliative Care and Pain Relief in Patients With Metastatic Prostate Cancer

Ba X. Hoang Ba X. Hoang, MD, PhD, is Medical Director, Bao T. Le, MD, MS, is an Attending Physician, Hau D. Tran, MD, MS, is an Attending Oncologist, and Cuong Hoang, MD, MS, is an Attending Physician at the Viet Xuan Medical Center, Hanoi, Vietnam.Correspondence[email protected]

Bao T. Le Ba X. Hoang, MD, PhD, is Medical Director, Bao T. Le, MD, MS, is an Attending Physician, Hau D. Tran, MD, MS, is an Attending Oncologist, and Cuong Hoang, MD, MS, is an Attending Physician at the Viet Xuan Medical Center, Hanoi, Vietnam.

Hau D. Tran Ba X. Hoang, MD, PhD, is Medical Director, Bao T. Le, MD, MS, is an Attending Physician, Hau D. Tran, MD, MS, is an Attending Oncologist, and Cuong Hoang, MD, MS, is an Attending Physician at the Viet Xuan Medical Center, Hanoi, Vietnam.

Cuong Hoang Ba X. Hoang, MD, PhD, is Medical Director, Bao T. Le, MD, MS, is an Attending Physician, Hau D. Tran, MD, MS, is an Attending Oncologist, and Cuong Hoang, MD, MS, is an Attending Physician at the Viet Xuan Medical Center, Hanoi, Vietnam.

Hung Q. Tran Hung Q. Tran, MD, PhD, is Head of Oncology Department, Dao M. Tran, MD, PhD, is Professor and Director of Hospital, and Cu Q. Pham, MD, PhD, is Professor and Head of Medical Service, at the 198 Hospital, Hanoi, Vietnam.

Dao M. Tran Hung Q. Tran, MD, PhD, is Head of Oncology Department, Dao M. Tran, MD, PhD, is Professor and Director of Hospital, and Cu Q. Pham, MD, PhD, is Professor and Head of Medical Service, at the 198 Hospital, Hanoi, Vietnam.

Cu Q. Pham Hung Q. Tran, MD, PhD, is Head of Oncology Department, Dao M. Tran, MD, PhD, is Professor and Director of Hospital, and Cu Q. Pham, MD, PhD, is Professor and Head of Medical Service, at the 198 Hospital, Hanoi, Vietnam.

Tuan D. Pham Tuan D. Pham, MD, Trung V. Ha, MD, MS, and Nga T. Bui, MD, are Attending Physicians at the Hospital of Ministry of Agricultural and Rural Development, Hanoi, Vietnam.

Trung V. Ha Tuan D. Pham, MD, Trung V. Ha, MD, MS, and Nga T. Bui, MD, are Attending Physicians at the Hospital of Ministry of Agricultural and Rural Development, Hanoi, Vietnam.

Nga T. Bui Tuan D. Pham, MD, Trung V. Ha, MD, MS, and Nga T. Bui, MD, are Attending Physicians at the Hospital of Ministry of Agricultural and Rural Development, Hanoi, Vietnam.

D. Graeme Shaw D. Graeme Shaw, MD, is an Internist in private practice in Los Altos, California, USA.

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ABSTRACT

Prostate cancer (adenocarcinoma of the prostate) is the most widespread cancer in men. It causes significant suffering and mortality due to metastatic disease. The main therapy for metastatic prostate cancer (MPC) includes androgen manipulation, chemotherapy, and radiotherapy and/or radioisotopes. However, these therapeutic approaches are considered palliative at this stage, and their significant side effects can cause further decline in patients’ quality of life and increase non–cancer-related morbidity/mortality. In this study, the authors have used the infusion of dimethyl sulfoxide–sodium bicarbonate (DMSO-SB) to treat 18 patients with MPC. The 90-day follow-up of the patients having undergone the proposed therapeutic regimen showed significant improvement in clinical symptoms, blood and biochemistry tests, and quality of life. There were no major side effects from the treatment. In searching for new and better methods for palliative treatment and pain relief, this study strongly suggested therapy with DMSO-SB infusions could provide a rational alternative to conventional treatment for patients with MPC.

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Dimethyl Sulfoxide–Sodium Bicarbonate Infusion for Palliative Care and Pain Relief in Patients With Metastatic Prostate Cancer

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Dimethyl Sulfoxide–Sodium Bicarbonate Infusion for Palliative Care and Pain Relief in Patients With Metastatic Prostate Cancer

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