Diseases caused by defects of energy level and loss of coherence in living cells

Abstract

Human and animal diseases are brought about by pathological alterations of production, composition, and conformation of macromolecules and structures in cells. Additional contributing factors include changes in physiological states caused by disturbances of energy supply, energy transduction, energy dissipation in moving or oscillating parts, and parasitic energy consumption. Disturbances of energy states may endanger existence of the system. The cell-mediated immunity (CMI) response of T lymphocytes correlating with their adherence properties was examined using antigen prepared from the serum of inbred laboratory mice strain C3H H^2k infected with lactate dehydrogenase elevating (LDH) virus. LDH virus is a parasite on the cellular energy system. Significant CMI response was elicited in T lymphocytes prepared from the blood of patients with cancer of different phenotypes, acute myocardial infarctions, schizophrenia, and recurrent spontaneous abortions in early pregnancy from unknown reasons. The CMI response is assumed to monitor transferred information about decreased levels of energy states and decoherence in the cells caused by mitochondrial malfunction, parasitic consumption, production of lactate, and possibly other disturbances. The LDH virus infection or similar pathological processes caused by different agents might be connected with the diseases and monitored by the examined CMI response. A large amount of mitoses with chromosome defects in aborted fetuses suggest increased mutability of genomes caused by defective energy states.

• Cell-mediated immunity response
• LDH virus antigen
• cancer
• acute myocardial infarction
• schizophrenia
• spontaneous abortion from unknown reasons
• pathological energy states

Acknowledgment

The authors pay tribute to the late Professor Emilio Del Giudice for his pioneering contributions to the application of quantum electrodynamics to biology, for his scientific support of the Prague symposia on biophysical aspects of cancer since 1987, and for his great humanistic attitude to science and life. We also keep alive the memory and names of our colleagues Josef Koštíř, Karel Heyberger, Tomáš Hraba, Jiří Čoupek, Blanka Mejsnarová, and Oto Wichterle who made the greatest contribution to the development of materials and facilities necessary for antigen purification.

Declaration of interest

The authors report that they have no conflicts of interest.