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Abstract
The second generation of female OF1 mice exposed chronically to an ELF field of 50 Hz and 15 μT (rms), generated in a Helmholtz coil system, was studied to determine the possible protein changes in the skeletal muscle associated with this exposure. Animals were sacrificed at the age of 14 weeks, and their quadriceps skeletal muscles were studied by electron microscope immunocytochemistry to detect the possible changes in different proteins. Actin, myosin, desmin, and vimentin immunolabeling was found to be similar in both control (unexposed) and experimental (exposed) animals. Dystrophin was found to increase in the sarcoplasmic reticulum in the exposed animals with respect to the control ones. α-Actinin was found to increase in some damaged Z-bands of the experimental animals; troponin and calmodulin increased all along the sarcomere of the muscles of the exposed mice, whereas titin and nebulin immunoreactions decreased in the sarcomeres of the experimental group. The observed changes in these proteins should affect the contraction process.