Kinetics of MRI Contrast Agents with a Size Ranging Between Gd-DTPA and Albumin-Gd-Dtpa Use of CASCADE-Gd-DTPA-24 Polymer

Franci Demsar Department of Radiology, University of California, San Francisco, California; Jozef Stefan Institute, University of Ljubljana, Ljubljana, SloveniaCorrespondence[email protected]

David M. Shames Department of Radiology, University of California, San Francisco, California

Timothy P. L. Roberts Department of Radiology, University of California, San Francisco, California

Michael Stiskal Department of Radiology, University of California, San Francisco, California

Heidi C. Roberts Department of Radiology, University of California, San Francisco, California

Robert C. Brasch Department of Radiology, University of California, San Francisco, California

Abstract

A unified kinetic theory describing the dynamic properties of magnetic resonance imaging (MRI) contrast agents with a size ranging between that of Gd-DTPA and albumin-(Gd-DTPA)₃₀ was developed and tested in disease models of cancer and myocardial reperfusion injury. Specifically, a two-compartment kinetic model was solved analytically, and a range of special cases of the model was studied. MRI was performed with strongly T₁-weighted sequences before and dynamically after administration of albumin-(Gd-DTPA)₃₀, a prototype macromolecular contrast medium (MMCM) designed for blood-pool enhancement; a new MMCM: Gd-DTPA-cascade polymer (Schering AG, Berlin, Germany, MW < 30 kDa); or Gd-DTPA, representing small paramagnetic extracellular agents. The greatest dynamic range of contrast-agent sensitivity to disease was found for albumin-(Gd-DTPA)₃₀.

Key Words:

MRI macromolecular contrast agents

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Kinetics of MRI Contrast Agents with a Size Ranging Between Gd-DTPA and Albumin-Gd-Dtpa Use of CASCADE-Gd-DTPA-24 Polymer

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Kinetics of MRI Contrast Agents with a Size Ranging Between Gd-DTPA and Albumin-Gd-Dtpa Use of CASCADE-Gd-DTPA-24 Polymer

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