Desmosomal Adhesion In Vivo

Abstract

Desmosomes are intercellular junctions that provide strong adhesion or hyper-adhesion in tissues. Here, we discuss the molecular and structural basis of this with particular reference to the desmosomal cadherins (DCs), their isoforms and evolution. We also assess the role of DCs as regulators of epithelial differentiation. New data on the role of desmosomes in development and human disease, especially wound healing and pemphigus, are briefly discussed, and the importance of regulation of the adhesiveness of desmosomes in tissue dynamics is considered.

Keywords::

• desmosome
• cell–cell adhesion
• desmocollin
• desmoglein
• desmosomal cadherin
• development
• wound healing
• pemphigus

Declaration of interest: The authors report no declaration of interest. The authors alone are responsible for the content and writing of the paper.