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Research Article

Two cases of wiskott–Aldrich syndrome in neonates due to gene mutations

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Pages 312-315 | Received 27 Aug 2012, Accepted 19 Nov 2012, Published online: 10 Jan 2013
 

Abstract

Wiskott–Aldrich syndrome (WAS) is a rare X-linked recessive disease characterized by eczema, thrombocytopenia and immune deficiency. WAS gene mutations impair WAS protein function which cause WAS. The WAS-related disorders of X-linked thrombocytopenia (XLT) and X-linked congenital neutropenia (XLN) may have similar but less severe symptoms those are also caused by mutations of the same gene. We present two cases of WAS in neonates with WAS gene mutations. Early genetic diagnosis can help to the treatment and prevention this disease.

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