Acth-Producing Microadenoma of the Pituitary in A Young Female Infant with Cushing's Disease: Report of a Case Including Immunocytologic and Ultrastructural Studies

Man-Soo Kim Department of Pathology and Department of Endocrinology, Hospital for Sick Children, Toronto, Ontario, Canada, M5G 1X8

Gregory J. Wilson Department of Pathology and Department of Endocrinology, Hospital for Sick Children, Toronto, Ontario, Canada, M5G 1X8

F. John Holland Department of Pathology and Department of Endocrinology, Hospital for Sick Children, Toronto, Ontario, Canada, M5G 1X8

Kalman Kovacs Department of Pathology, St. Michael's Hospital, Toronto, Ontario, Canada, MSB 1W8

Abstract

A female infant, younger than any other case in the literature, with ACTH-producing microadenoma of the pituitary is reported. She had full-blown symptoms and signs as well as laboratory evidence of Gushing's disease. The tumor was investigated by histology, immunocy-tology (avidin-biotin-peroxidase complex technique), and electron microscopy. The possibility that the tumor was derived from the fetal intermediate lobe is discussed.

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Acth-Producing Microadenoma of the Pituitary in A Young Female Infant with Cushing's Disease: Report of a Case Including Immunocytologic and Ultrastructural Studies

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Acth-Producing Microadenoma of the Pituitary in A Young Female Infant with Cushing's Disease: Report of a Case Including Immunocytologic and Ultrastructural Studies

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