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Pediatric Pathology Volume 6, 1986 - Issue 2-3
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Original Article

Adrenoleukodystrophy: Evidence for Cytoplasmic Inclusions in White Blood Cells

Juan Chemke Clinical Genetics Unit, Kaplan Hospital, Rehovot, 76100, Israel
,
Nelly Livni Department of Pathology, Hebrew University and Hadassah Medical School, Jerusalem, Israel
&
Eliezer Rosenmann Department of Pathology, Hebrew University and Hadassah Medical School, Jerusalem, Israel
Pages 173-179 | Received 21 Aug 1984, Accepted 05 Dec 1984, Published online: 09 Jul 2009
 
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Abstract

Adrenoleukodystrophy (ALD) is a progressive neurological demyelinating disease associated with adrenal insufficiency. Pathognomonic lamellar profiles and clear clefts have been observed in several organs and tissues. We describe similar ultrastructural lamellar lipid profiles in white blood cells from 2 patients with ALD. It is suggested that electron microscopy of white blood cells may be a simple and effective screening method in patients presenting with a clinical picture suggestive of ALD.

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