325
Views
5
CrossRef citations to date
0
Altmetric
Critical Care

An exploratory study; the therapeutic effects of premixed activated charcoal–sorbitol administration in patients poisoned with organophosphate pesticide

, &
Pages 119-126 | Received 03 Sep 2014, Accepted 17 Dec 2014, Published online: 22 Jan 2015
 

Abstract

Objective. The effects of activated charcoal (AC) mixed with cathartics for gastric decontamination in the management of organophosphate (OP) poisoning remain unknown due to limited clinical evidence. This exploratory study assessed the effectiveness of premixed AC–sorbitol as a treatment for OP poisoning. Materials and methods. This retrospective observational case study included patients who either did not receive AC–sorbitol or received a single dose of AC–sorbitol within 24 h after OP ingestion. The patients were divided into three groups: no AC–sorbitol treatment, patients who received AC–sorbitol within 1 h of OP ingestion, and patients who received AC–sorbitol more than 1 h after OP ingestion. Mortality, the development of respiratory failure, and the duration of mechanical ventilation were used as outcome measurements for effectiveness, whereas aspiration pneumonia and electrolyte imbalance were employed as safety measurements. Result. Among 262 patients with OP poisoning, 198 were included. Of these, 133 patients did not receive AC–sorbitol, whereas 14 and 51 patients received AC–sorbitol within 1 h or more than 1 h after ingestion, respectively. The time from ingestion to hospital arrival and time from ingestion to administration of atropine and pralidoxime differed among the groups, whereas other characteristics, including age, amount ingested, and type of ingested OP, were similar among the groups. Univariate and multivariate analysis demonstrated that the administration of AC–sorbitol was not associated with outcome measures for effectiveness and did not significantly increase either aspiration pneumonia or electrolyte imbalances during hospitalization. Discussion and conclusion. The administration of AC–sorbitol exerted neither beneficial nor harmful effects on the outcomes of OP-poisoned patients regardless of the time from OP ingestion to administration, compared with those of patients who did not receive AC–sorbitol. However, this study enrolled a small number of patients who received AC–sorbitol; further qualified trials with a sufficient number of patients are therefore needed.

Declaration of interest

The authors report no declarations of interest. The authors alone are responsible for the content and writing of the paper.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.