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Abstract
Context. The toxicokinetics of sustained-release bupropion are not well described. Case. A 23-year-old Caucasian male took an overdose of 5,700 mg of sustained release bupropion with no co-ingestant. Venous serum samples were assayed for bupropion concentrations over the next 5 days. The peak concentration was 1.114 mg/L. The observed Tmax was found to be 8.25 h, the calculated alpha half-life 10.9 h (±SE of 4.47%), and the calculated beta half-life 19.8 h (±SE 12.62%). The alpha half-life and Tmax differ significantly from those seen in therapeutic doses. Discussion. Bezoar formation may underlie these differences. Interventions which reduce the absorption of sustained release bupropion may be effective in overdose.
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