Plasmapheresis in Thyroxine Overdose: A Case Report

Michael E. May Divisions of Clinical Pharmacology and Endocrinology and Metabolism Departments of Medicine and Pharmacology, University of Virginia, Charlottesville, Virginia, 22908

Paul D. Mintz Divisions of Clinical Pharmacology and Endocrinology and Metabolism Departments of Medicine and Pharmacology, University of Virginia, Charlottesville, Virginia, 22908

Philip Lowry Divisions of Clinical Pharmacology and Endocrinology and Metabolism Departments of Medicine and Pharmacology, University of Virginia, Charlottesville, Virginia, 22908

Robert Geller Divisions of Clinical Pharmacology and Endocrinology and Metabolism Departments of Medicine and Pharmacology, University of Virginia, Charlottesville, Virginia, 22908

Randall T. Curnow Divisions of Clinical Pharmacology and Endocrinology and Metabolism Departments of Medicine and Pharmacology, University of Virginia, Charlottesville, Virginia, 22908

Abstract

Thyrotoxicosis from an overdose of medicinal thyroid is a condition which may be associated with a significant delay in onset of toxicity. We report a case treated with plasmapheresis, and conclude that the amount of thyroid hormone removed was insignificant compared to the total ingestion. We also note that the plasma half-life of thyroxine is apparently reduced in an acute massive ingestion.

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Plasmapheresis in Thyroxine Overdose: A Case Report

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Plasmapheresis in Thyroxine Overdose: A Case Report

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