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Abstract
We have previously shown that ferrous and ferric ions readily form complexes with magnesium hydroxide [Mg(OH)2] thus reducing the absorption of iron salts from the gastrointestinal tract. The present study answers the following question: what is the optimal dose, time of administration, optimal limit of effectiveness, and potential hazard of this form of therapy. Adult mongrel dogs were administered ferrous sulfate [FeSO], tablets at a dosage of 650 mg/lb of body weight. Either 30 or 60 minutes later, the dogs were given Mg(OH)2 at either 5 or 10 times the dose of elemental iron. Serum iron concentrations in all animals given Mg(OH)2 were significantly lower (p<0.05) than those of control animals. No significant differences were observed regardless of dose or time of administration of Mg(OH)2. Although serum Mg concentrations were significantly elevates (p<0.05) in all treated animals 4 and 6 hr post iron, no clinical manifestations of hypermagnesemia were observed. These studies demonstrate the effectiveness of Mg(OH)2 in the management of experimental iron intoxication and warrant a controlled clinical trial in humans.