Pharmacokinetics of Oral and Intravenous Bromide in Normal Volunteers

Nachum Vaiseman Division of Clinical Nutrition The Department of Pediatrics The Hospital for Sick children, and the Departments of Pediatrics and Pharmacology, The Research Institute, University of Toronto, Ontario, Canada

Gideon Koren Clinical Pharmacology The Department of Pediatrics, The Hospital for Sick children, and the Departments of Pediatrics and Pharmacology, The Research Institute, University of Toronto, Ontario, Canada

Paul Pencharz Division of Clinical Nutrition The Department of Pediatrics The Hospital for Sick children, and the Departments of Pediatrics and Pharmacology, The Research Institute, University of Toronto, Ontario, Canada

Abstract

The pharmacokinetics of oral and intravenous bromide was studied in 7 adult volunteers, who served as their own controls. They received 1 ml/kg of 3% sodium bromide, equivalent to 30 mg/kg bromide.

Oral bioavailability ranged between 75-118% with a mean of 96 ± 6%. Elimination T_1/2 was 11.9 ± 1.4 days after oral administration and 9.4 ± 1.5 days after I.V. administration (P > 0.10). The employment of this ion for calculation of extracellular fluid and assessment of its potential significance in environmental toxicology necessitates accurate data on its disposition characteristics.

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Pharmacokinetics of Oral and Intravenous Bromide in Normal Volunteers

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Pharmacokinetics of Oral and Intravenous Bromide in Normal Volunteers

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