Acute Arsenical Myopathy: Morphological Description

J. Fernandez-Sola Department of Internal Medicine, Muscle Research Group, Barcelona, Spain

S. Nogue Toxicology Unit, Hospital Clinic, University of Barcelona Villarroel, Barcelona, Spain

J. M. Grau Department of Internal Medicine, Muscle Research Group, Barcelona, Spain

J. Casademont Department of Internal Medicine, Muscle Research Group, Barcelona, Spain

P. Munne Toxicology Unit, Hospital Clinic, University of Barcelona Villarroel, Barcelona, Spain

Abstract

We describe the histological findings of the muscle in a case of acute voluntary massive arsenic intoxication resulting in severe rhabdomyolysis. The main features on muscle biopsy were perifascicular hypercontracted fibers, myofibrillar disruption, mitochondrial abnormalities and abundant cytoplasmic vacuoles containing lipids.

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Acute Arsenical Myopathy: Morphological Description

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