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Research Article

Folinic Acid and Enhanced Renal Elimination in Formic Acid Intoxication

, , , &
Pages 199-204 | Published online: 25 Sep 2008
 

Abstract

Ingestion of over 60 g of formic acid by an adult is potentially fatal. We report a case of a 36-year-old woman with a history of depression who ingested 110 g of formic acid. She survived a complicated intensive care hospitalization following usage of intravenous folinic acid, urinary alkalinization, intravenous furosemide and supportive care. We suggest a management protocol aimed at minimizing formate toxicity by enhancing hepatic formate degradation via the folinic acid one carbon pool and by enhanced renal elimination of formate.

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