Cholinergic Toxicity Resulting from Ocular Instillation of Echothiophate Iodide Eye Drops

Anthony Manoguerra San Diego Regional Poison Center, University of California, San Diego Medical Center; Mission Bay Hospital, San Diego, California

Charles Whitney San Diego Regional Poison Center, University of California, San Diego Medical Center; Mission Bay Hospital, San Diego, California

Richard F. Clark San Diego Regional Poison Center, University of California, San Diego Medical Center; Mission Bay Hospital, San Diego, California

Bruce Anderson San Diego Regional Poison Center, University of California, San Diego Medical Center; Mission Bay Hospital, San Diego, California

Steven Turchen San Diego Regional Poison Center, University of California, San Diego Medical Center; Mission Bay Hospital, San Diego, California

Abstract

A patient developed a severe cholinergic syndrome from the use of echothiophate iodide ophthalmic drops, presented with profound muscle weakness and was initially given the diagnosis of myasthenia gravis. Red blood cell and serum cholinesterase levek were severely depressed andsymptoms resolved spontaneously following discontinuation of the eye drops.

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Cholinergic Toxicity Resulting from Ocular Instillation of Echothiophate Iodide Eye Drops

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Cholinergic Toxicity Resulting from Ocular Instillation of Echothiophate Iodide Eye Drops

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