Effects of Alkalinity on the Eye Irritation Potential of Solutions Prepared at a Single pH

Abstract

To determine the effects of solution alkalinity on eye irritation, a modified Draize eye irritancy test was performed using 3 differently buffered solutions, at specified alkalinities, set at a pH of 11.5. The maximum average Draize score and median days to clear indicated that solutions with a low buffering capacity are not necessarily irritants at a pH considered to indicate high eye irritation potential.