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Abstract
Guinea pigs were dermally exposed to the hairdye paraphenylenediamine (PPD) for 15 and 30 days to assess the effects on selected enzyme activities, lipid peroxidation, and histamine content in the skin. The activities of acid phosphatase, glutathione-s-transferase, and tyrosinase were enhanced after application of PPD. The lipid peroxidation, histamine, and PPD content of skin also showed marked elevation following dermal exposure to the chemical.