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Toxin Reviews Volume 31, 2012 - Issue 3-4
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Review Article

Overview on aflatoxins and oxidative stress

Daniela E. MarinLaboratory of Animal Biology, National Institute for Research and Development for Biology and Animal Nutrition, Calea Bucuresti no. 1, Balotesti, Ilfov, 077015, RomaniaCorrespondence[email protected]
&
Ionelia TaranuLaboratory of Animal Biology, National Institute for Research and Development for Biology and Animal Nutrition, Calea Bucuresti no. 1, Balotesti, Ilfov, 077015, Romania
Pages 32-43 | Received 31 Jul 2012, Accepted 20 Aug 2012, Published online: 24 Oct 2012
 
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Abstract

Aflatoxins are naturally occurring mycotoxins that are produced by many species of Aspergillus, a fungus, mainly by Aspergillus flavus and Aspergillus parasiticus. Aflatoxins, especially aflatoxin B1 (AFB1), are very potent carcinogens in many species, including humans, birds, swine, fish, and rodents. The oxidative stress caused by AFB1 may be one of the underlining mechanisms for AFB1-induced cell injury and DNA, protein and lipid damages, which lead to tumorigenesis. This review presents an overview on aflatoxins and oxidative stress, with an emphasis on the protective role of the antioxidants.

Acknowledgment

The authors want to thank to Dr. Olga Starodub for her help with the English corrections.

Declaration of interest

This work was financed through the project Research and Development Project from the Nucleus Programme no 09-38 0104.

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