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Abstract
Low molecular weight partially purified inhibitory polypeptides were isolated from normal livers and liver tumours induced with DEN. Both the polypeptide fractions caused inhibition of 3H-Thymidine incorporation into primary hamster dermal fibroblasts. The polypeptide fractions were effective at as low a concentration as 10 μg/ml tested and the percentage of inhibition increased with increase in the concentration, attaining about 75-80% inhibition at 40 μg/ml concentration. SDS-PAGE and molecular sieve HPLC-analysis showed presence of four polypeptides in both the fractions. It appears that the imbalance between the loss and synthesis of some polypeptide factors with biological activity may be conferring growth advantage during carcinogenesis.