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Journal of Toxicology: Toxin Reviews Volume 18, 1999 - Issue 3-4
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Original

Mycotoxins as Causal Factors of Diseases in Humans

P. S. Steyn SASOL Centre for Chemistry, Potchefstroom University, Private Bag X6001, Potchefstroom 2520, Republic of South Africa
&
MA. Stander SASOL Centre for Chemistry, Potchefstroom University, Private Bag X6001, Potchefstroom 2520, Republic of South Africa
Pages 229-243 | Published online: 24 Sep 2010
 
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Abstract

The criteria of human mycotoxicoses are discussed and the role of certain mycotoxins in human diseases highlighted, e.g. ergotoxins (ergotism), trichothecenes, T2-toxin (alimentary toxic aleukia), aflatoxins (primary liver cancer), ochratoxins (Balkan Endemic Nephropathy and chronic interstitial nephropathy) and fumonisins (oesophogeal cancer). The chemical properties and biochemical mechanism of action of aflatoxin B1 ochratoxin A and fumonisin B1 are discussed.

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