Advanced search
Publication Cover
Nanotoxicology Volume 6, 2012 - Issue 7
Submit an article Journal homepage
903
Views
130
CrossRef citations to date
0
Altmetric
Research Article

Size and surface charge significantly influence the toxicity of silica and dendritic nanoparticles

Khaled GreishDepartment of Pharmaceutics and Pharmaceutical Chemistry, University of Utah, Salt Lake City, UT, USA;Utah Center for Nanomedicine, Nano Institute of Utah, University of Utah, Salt Lake City, UT, USA
,
Giridhar ThiagarajanUtah Center for Nanomedicine, Nano Institute of Utah, University of Utah, Salt Lake City, UT, USA;Department of Bioengineering, University of Utah, Salt Lake City, UT, USA
,
Heather HerdUtah Center for Nanomedicine, Nano Institute of Utah, University of Utah, Salt Lake City, UT, USA;Department of Bioengineering, University of Utah, Salt Lake City, UT, USA
,
Robert PriceDepartment of Pharmaceutics and Pharmaceutical Chemistry, University of Utah, Salt Lake City, UT, USA;Utah Center for Nanomedicine, Nano Institute of Utah, University of Utah, Salt Lake City, UT, USA
,
Hillevi BauerDepartment of Pharmaceutics and Pharmaceutical Chemistry, University of Utah, Salt Lake City, UT, USA;Utah Center for Nanomedicine, Nano Institute of Utah, University of Utah, Salt Lake City, UT, USA
,
Dallin HubbardUtah Center for Nanomedicine, Nano Institute of Utah, University of Utah, Salt Lake City, UT, USA;Department of Bioengineering, University of Utah, Salt Lake City, UT, USA
,
Alexander BurckleUtah Center for Nanomedicine, Nano Institute of Utah, University of Utah, Salt Lake City, UT, USA;Department of Bioengineering, University of Utah, Salt Lake City, UT, USA
,
Shraddha SadekarDepartment of Pharmaceutics and Pharmaceutical Chemistry, University of Utah, Salt Lake City, UT, USA;Utah Center for Nanomedicine, Nano Institute of Utah, University of Utah, Salt Lake City, UT, USA
,
Tian YuDepartment of Pharmaceutics and Pharmaceutical Chemistry, University of Utah, Salt Lake City, UT, USA;Utah Center for Nanomedicine, Nano Institute of Utah, University of Utah, Salt Lake City, UT, USA
,
Arnida AnwarDepartment of Pharmaceutics and Pharmaceutical Chemistry, University of Utah, Salt Lake City, UT, USA;Utah Center for Nanomedicine, Nano Institute of Utah, University of Utah, Salt Lake City, UT, USA
,
Abhijit RayDepartment of Pharmaceutics and Pharmaceutical Chemistry, University of Utah, Salt Lake City, UT, USA;Utah Center for Nanomedicine, Nano Institute of Utah, University of Utah, Salt Lake City, UT, USA
&
Hamidreza GhandehariDepartment of Pharmaceutics and Pharmaceutical Chemistry, University of Utah, Salt Lake City, UT, USA;Utah Center for Nanomedicine, Nano Institute of Utah, University of Utah, Salt Lake City, UT, USA;Department of Bioengineering, University of Utah, Salt Lake City, UT, USACorrespondence[email protected]
 show all
Pages 713-723 | Received 29 Dec 2010, Accepted 05 Jul 2011, Published online: 28 Jul 2011
 
Sample our Bioscience journals, sign in here to start your access, Latest two full volumes FREE to you for 14 days

Abstract

The influence of size, surface charge and surface functionality of poly(amido amine) dendrimers and silica nanoparticles (SNPs) on their toxicity was studied in immunocompetent mice. After systematic characterization of nanoparticles, they were administered to CD-1 (caesarean derived-1) mice to evaluate acute toxicity. A distinct trend in nanotoxicity based on surface charge and functional group was observed with dendrimers regardless of their size. Amine-terminated dendrimers were fatal at doses >10 mg/kg causing haematological complications such as disseminated intravascular coagulation-like manifestations whereas carboxyl- and hydroxyl-terminated dendrimers of similar sizes were tolerated at 50-fold higher doses. In contrast, larger SNPs were less tolerated than smaller SNPs irrespective of their surface functionality. These findings have important implications in the use of these nanoparticles for various biomedical applications.

Acknowledgements

Financial support was provided by NIH Grants (R01DE019050 and R01EB07470) and the Utah Science Technology and Research (USTAR) initiative.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related Research Data

Adsorption at cell surface and cellular uptake of silica nanoparticles with different surface chemical functionalizations: impact on cytotoxicity
Source: HAL CCSD
Introduction—Biointeractions of Nanomaterials: Challenges and Solutions
Source: CRC Press
The application of nanotechnology in enhancing immunotherapy for cancer treatment: current effects and perspective
Source: Royal Society of Chemistry (RSC)
A triple modality BSA-coated dendritic nanoplatform for NIR imaging, enhanced tumor penetration and anticancer therapy.
Source: Royal Society of Chemistry (RSC)
Dendrimers as Powerful Building Blocks in Central Nervous System Disease: Headed for Successful Nanomedicine
Source: Wiley
Interlaboratory comparison of size measurements on nanoparticles using nanoparticle tracking analysis (NTA)
Source: Springer Nature
Nanoparticles: Cellular Uptake and Cytotoxicity
Source: Springer Netherlands
Assessment of interactions of efavirenz solid drug nanoparticles with human immunological and haematological systems.
Source: BMC
The inhibitory effect of carboxyl-terminated polyamidoamine dendrimers on dentine host-derived matrix metalloproteinases in vitro in an etch-and-rinse adhesive system.
Source: The Royal Society
The effect of PAMAM dendrimer concentration, generation size and surface functional group on the aqueous solubility of candesartan cilexetil
Source: Taylor & Francis
Transient Receptor Potential Ion Channel-Dependent Toxicity of Silica Nanoparticles and Poly(amido amine) Dendrimers.
Source: American Society for Pharmacology & Experimental Therapeutics (ASPET)
Comparative cytotoxicity and genotoxicity of cobalt (II, III) oxide, iron (III) oxide, silicon dioxide, and aluminum oxide nanoparticles on human lymphocytes in vitro:
Source: SAGE Publications

Linking provided by 

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.