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Abstract
Background and purpose High-volume infiltration analgesia may be effective in postoperative pain management after hip arthroplasty but methodological problems prevent exact interpretation of previous studies.
Methods In a randomized, double-blind placebo-controlled trial in 12 patients undergoing bilateral total hip arthroplasty (THA) in a fast-track setting, saline or high-volume (170 mL) ropivacaine (0.2%) with epinephrine (1:100,000) was administered to the wound intraoperatively along with supplementary postoperative injections via an intraarticular epidural catheter. Oral analgesia was instituted preoperatively with a multimodal regimen (gabapentin, celecoxib, and acetaminophen). Pain was assessed repeatedly for 48 hours postoperatively, at rest and with 45° hip flexion.
Results Pain scores were low and similar between ropivacaine and saline administration. Median hospital stay was 4 (range 2–7) days.
Interpretation Intraoperative high-volume infiltration with 0.2% ropivacaine with repeated intraarticular injections postoperatively may not give a clinically relevant analgesic effect in THA when combined with a multimodal oral analgesic regimen with gabapentin, celecoxib, and acetaminophen.
LØA: Inclusion of patients, data registration and analysis, anaesthetic procedures and writing of manuscript. KSO and HH: Surgical procedures and contributions to manuscript. LGL: Inclusion of patients and data registration. BK: Anaesthetic procedures, preparation of study medicine and contributions to manuscript. HK: Academic contributions
We thank Dr Kerr and Dr Kohan, St. Lukes Hospital, Sydney, Australia, for teaching us the technique of high-volume infiltration analgesia. The study was supported by the Lundbeck Foundation and IMK Almene Fond, Copenhagen, Denmark.
