The Penetration of Lincomycin into Normal Human Bone: Determinations of Penetration into Compact Bone, Spongy Bone and Bone Marrow

M. Lykkegaard Nielsen Department of Orthopaedic Surgery, Rigshospitalet, Department of Clinical Microbiology, The Institute of Medical Microbiology, University of Copenhagen, Denmark

I. Hansen Department of Orthopaedic Surgery, Rigshospitalet, Department of Clinical Microbiology, The Institute of Medical Microbiology, University of Copenhagen, Denmark

J. Boss Nielsen Department of Orthopaedic Surgery, Rigshospitalet, Department of Clinical Microbiology, The Institute of Medical Microbiology, University of Copenhagen, Denmark

Abstract

The penetration of lincomycin into normal bone was studied in 10 patients with fracture of the neck of the femur, a separate determination being made of the lincomycin concentration in serum, bone marrow, spongy bone and compact bone. The concentration of lincomycin in bone marrow was found to be at the same level as that in the serum. The concentration in spongy bone amounted in most cases to 50 to 75 per cent of the concentration in the serum, whereas the concentration in compact bone varied from 0 to 15 per cent of that in the serum.

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The Penetration of Lincomycin into Normal Human Bone: Determinations of Penetration into Compact Bone, Spongy Bone and Bone Marrow

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The Penetration of Lincomycin into Normal Human Bone: Determinations of Penetration into Compact Bone, Spongy Bone and Bone Marrow

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