Indomethacin Influences Moloney's Sarcoma and Associated Periosteal Osteogenesis in the Mouse

Abstract

The effect of indomethacin on periosteal osteogenesis mediated by the Moloney sarcoma virus was studied using a mouse model. In the indomethacin-treated animals, the development of sarcoma was inhibited, as evaluated by the tumor incidence, tumor size, and maximal tumor duration. Periosteal osteogenesis mediated by this sarcoma was lower than in saline-treated control mice.