Inhibition of bacterial adhesion by tobramycinimpregnated PMMA bone cement

Masayoshi Oga Department of Orthopedics, Faculty of Medicine, Kyushu University, Fukuoka, 812, Japan, Tel +81 -92 641 1151, Fax +81 -92 632 1793

Takeshi Arizono Department of Orthopedics, Faculty of Medicine, Kyushu University, Fukuoka, 812, Japan, Tel +81 -92 641 1151, Fax +81 -92 632 1793

Yoichi Sugioka Department of Orthopedics, Faculty of Medicine, Kyushu University, Fukuoka, 812, Japan, Tel +81 -92 641 1151, Fax +81 -92 632 1793

Abstract

We investigated the effect of tobramycin-impregnated polymethylmethacrylate (PMMA) bone cement on the adhesion and colonization of Staphylococcus epidermidis. The pattern of colonization was quanti-tated using plate count techniques and electron microscopy.

Colonization of the tobramycin-impregnated disc surface by adhesive bacteria was demonstrated but it was less than in the control disc. This finding suggests that tobramycin may reduce bacterial adherence and proliferation on the PMMA surface.

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Inhibition of bacterial adhesion by tobramycinimpregnated PMMA bone cement

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Inhibition of bacterial adhesion by tobramycinimpregnated PMMA bone cement

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