Collagen II turnover in joint diseases

A Robin Poole Joint Diseases LaboratoryShriners Hospital for Crippled Children, Division of Surgical Research, Department of Surgery, McGill University, 1529 Cedar Avenue, Montreal, Quebec, Canada, H3G 1A6, +1-514 849 6208, +1-514 842 5581

Fred Nelson Department of Human Metabolism and Clinical Biochemistry, University of Sheffield Medical School, Beech Hill Road, Sheffield, S10 2RX, UK

Anthony Hollander Department of Human Metabolism and Clinical Biochemistry, University of Sheffield Medical School, Beech Hill Road, Sheffield, S10 2RX, UK

Agnes Reiner Joint Diseases LaboratoryShriners Hospital for Crippled Children, Division of Surgical Research, Department of Surgery, McGill University, 1529 Cedar Avenue, Montreal, Quebec, Canada, H3G 1A6, +1-514 849 6208, +1-514 842 5581

Isabelle Pidoux Joint Diseases LaboratoryShriners Hospital for Crippled Children, Division of Surgical Research, Department of Surgery, McGill University, 1529 Cedar Avenue, Montreal, Quebec, Canada, H3G 1A6, +1-514 849 6208, +1-514 842 5581

Mirela Ionescu1 Joint Diseases LaboratoryShriners Hospital for Crippled Children, Division of Surgical Research, Department of Surgery, McGill University, 1529 Cedar Avenue, Montreal, Quebec, Canada, H3G 1A6, +1-514 849 6208, +1-514 842 5581

Abstract

Content and structure in cartilage Type II collagen is one of the primary structural components of hyaline cartilage, constituting approximately half the dry weight of extracellular matrix. It is composed of a triple helix of three identical a chains organized in fibrils within the extracellular matrix. Whereas these fibrils are ordinarily clearly visible throughout the matrix, close to the cell in the pericellular domain, their identity is often difficult to discern. It is here that there is likely more active turnover of collagen, such as in rheumatoid arthritis (Mansson et al. 1995).

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Collagen II turnover in joint diseases

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Collagen II turnover in joint diseases

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