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Abstract
Distinct HLA-DRB1 haplotypes may predispose patients with rheumatoid arthritis (RA) to a more aggressive disease course. This was suggested from data generated by retrospective analysis of disease patterns and profiles (Weyand et al. 1992). It has not been studied so far whether the presence or absence of DRB 1*0401, 0404, 0408 and DRB 1*0101 is associated with a difference in expression / up-regulation of effector molecules involved in articular matrix degradation.