The TNF-MMP-matrix network and serum markers for cartilage synthesis and degradation

Abstract

TNF has been shown to affect articular matrix integrity by different mechanisms; directly by inhibiting proteoglycan aggrecan synthesis and indirectly by up-regulating matrix metalloproteinases (MMPs) mediating collagen and proteoglycan aggrecan degradation. The net effect of TNF on articular matrix remodeling / degradation in rheumatoid arthritis and the effect of synovial TNF inhibition may be reflected in patients by changes in serum profiles of immunochemical markers which represent important research tools in the clinical development of novel anti-rheumatic agents.