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Research Article

Energy transfer from systole to diastole: A novel device-based approach for the treatment of diastolic heart failure

, , , , , , & show all
Pages 232-242 | Received 09 Jul 2011, Accepted 07 Oct 2011, Published online: 05 Dec 2011
 

Abstract

We hypothesized that attachment of elastic coil to the left ventricular (LV) wall, capable of exerting outward forces may allow the transfer of energy from systole to diastole and improve diastolic function.

Methods and results: An extra-ventricular-device, composed of a series of elastic elements interposed between spiral screws attached to the epimyocardium of the LV free-wall was developed. The hemodynamic and mechanical effects of the device were tested using a computerized model, an in vitro model utilizing a computerized-controlled fluid pump, eight healthy sheep and 10 mini-pigs induced with diastolic dysfunction by renal wrapping. The computerized and in vitro models predicted a reduction of the LV diastolic pressure curve and partial normalization of the pressure-volume loop. The sheep study demonstrated preservation of animal's wellbeing including maintaining cardiac mechanical function with stable energy transfer from systole to diastole throughout the 6 months follow-up. The mini-pigs study showed an increase in the early diastolic to systolic strain-rate ratio in the mid-endocardial level (23 ± 10%, P = 0.008) and an increase in early apical reverse rotation rate of 50% (P = 0.016 compared to control).

Conclusions: This study presents a novel concept of using a mechanical device to transfer energy from systole to diastole, potentially enhancing diastolic function.

Acknowledgements

The authors thank Boaz Nishri and Yaron Arbel for their contribution to the project.

Funding sources

This research was supported by CorAssist Cardiovascular Ltd, and the Office of the Chief Scientist, Israel.

Disclosures

Shemy Carasso, Ehud Schwammenthal, and Amir Elami, are medical consultants of CorAssist Cardiovascular Ltd. The device was invented by Yair Feld. Yair Feld, Shay Dubi and Yotam Riesner are shareholders in CorAssist Cardiovascular Ltd.

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