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Research Article

Neurofilament heavy subunit in cerebrospinal fluid: A biomarker of amyotrophic lateral sclerosis?

, , , , , & show all
Pages 144-147 | Received 01 Aug 2010, Accepted 15 Nov 2010, Published online: 04 Jan 2011
 

Abstract

The objectives of this study were to investigate the presence of the three neurofilament subunits, ubiquitin, proteasome and 3-nitrotyrosine, in CSF samples of ALS patients. CSF samples were obtained by lumbar puncture from 10 ALS patients and six controls. All samples were analysed by Western blotting. Results revealed that neurofilament heavy subunit was identified in 70% of ALS cases and we conclude that this subunit may be a promising biomarker for clinical diagnosis of ALS.

Acknowledgements

We thank Mário Ary Pires Neto, José Mauro Braz de Lima, Marly Pernes da Silva Loureiro and Marzia Puccioni Sohler for their support, and Lilian Ayres Sá, Heliomar Pereira Marcos and Suely Menezes da Cunha for their excellent technical assistance. This study was supported by FAPERJ, CNPq, CAPES, and FUJB.

Declaration of interest: The authors report no conflicts of interest. The authors alone are responsible for the content and writing of the paper.

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