Mitochondrial DNA response to high altitude: A new perspective on high-altitude adaptation

Abstract

Mitochondria are the energy metabolism centers of the cell. More than 95% of cellular energy is produced by mitochondrial oxidative phosphorylation. Hypoxia affects a wide range of energy generation and consumption processes in animals. The most important mechanisms limiting ATP consumption increase the efficiency of ATP production and accommodate the reduced production of ATP by the body. All of these mechanisms relate to changes in mitochondrial function. Mitochondrial function can be affected by variations in mitochondrial DNA, including polymorphisms, content changes, and deletions. These variations play an important role in acclimatization or adaptation to hypoxia. In this paper, the association between mitochondrial genome sequences and high-altitude adaptation is reviewed.

Keywords::

• Mitochondrial DNA
• variation
• high altitude
• adaptation

Declaration of interest : This research was supported by the Frontier subject of basic medicine of the Third Military Medical University (No. 2012XJQ08) and the 973 Project of China (No. 2012CB518201). The authors report no conflicts of interest. The authors alone are responsible for the content and writing of the paper.