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Abstract
Objectives: To reduce the mean molecular weight 
and to increase the effective polymerization ratio (REff) of polymerized human placenta hemoglobin (PolyPHb). Methods: Three factors of GDA-PolyPHb process such as the approach of feeding GDA (FGDA), hemoglobin concentration ([Hb]) and the molar ratio of GDA, and hemoglobin(RGDA:Hb) were investigated. Finally, the expansion experiments were conducted with optimal conditions. Results: The data showed that the HBOCs with the REff of 67.35% and lower 
of 162.70 kDa were prepared by optimal conditions. Conclusion: Compared to original process, the optimal process greatly decreased the 
and increased the REff.
Declaration of interest
The authors report no declarations of interest. The authors alone are responsible for the content and writing of the paper.
Supported by National High-tech R&D Program of China (863 Program) (Grant No. 2012AA021903).