Hemodynamic recovery after hypovolemic shock with lactated Ringer's and keratin resuscitation fluid (KRF), a novel colloid

Abstract

Death after severe hemorrhage remains an important cause of mortality in people under 50 years of age. Keratin resuscitation fluid (KRF) is a novel resuscitation solution made from keratin protein that may restore cardiovascular stability. This postulate was tested in rats that were exsanguinated to 40% of their blood volume. Test groups received either low or high volume resuscitation with either KRF or lactated Ringer's solution. KRF low volume was more effective than LR in recovering cardiac function, blood pressure and blood chemistry. Furthermore, in contrast to LR-treated rats, KRF-treated rats exhibited vital signs that resembled normal controls at 1-week.

Keywords::

• Hyperoncotic
• resuscitation
• hyperviscous colloid
• hypovolemia
• keratin biomaterials
• keratose
• low volume resuscitation
• permissive hypotension

Declaration of interest

Author Mark van Dyke holds stock and is an officer in the company, KeraNetics LLC. Author Luke Burnett is currently an employee of KeraNetics LLC. Wake Forest School of Medicine has a potential financial interest in KeraNetics through licensing agreements. Drs. Van Dyke and Burnett have a potential conflict of interest.

Funding Sources

Partial funding for this project was provided by KeraNetics LLC and NIH/NHLBI (grant no. 1R43HL099010-01A1).