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Abstract
The aim of present study was to evaluate the potential of mucoadhesive alginate-coated chitosan microparticles (A-CHMp) for oral vaccine against anthrax. The zeta potential of A-CHMp was − 29.7 mV, and alginate coating could prevent the burst release of antigen in simulated gastric fluid. The results indicated that A-CHMp was mucoadhesive in nature and transported it to the peyer's patch upon oral delivery. The immunization studies indicated that A-CHMp resulted in the induction of potent systemic and mucosal immune responses, whereas alum-adjuvanted rPA could induce only systemic immune response. Thus, A-CHMp represents a promising acid carrier adjuvant for oral immunization against anthrax.
Acknowledgement
We are thankful to Dr. Yogendra Singh (IGIB, New Delhi) for providing recombinant Protective Antigen and Lethal Factor and Raj Kurupati (IGIB, New Delhi) for his cooperation, support, and help. We are thankful to Indian Institute of Technology (Bombay), All India Institute of Medical Sciences (AIIMS) and Punjab University (PU) for providing SAIF facility. The authors would also like to acknowledge All India Council of Technical Education (AICTE) for providing Junior Research Fellowship (JRF) to carry out the research work.
Declaration of interest
The authors report no declarations of interest. The authors alone are responsible for the content and writing of the paper.
