Stimuli-sensitive Systems-an emerging delivery system for drugs

Abstract

Objectives: Development of controlled and sustained drug delivery system (DDS) remains a great thrust of human beings for the successful delivery of drugs due to various drawbacks of existing systems. In order to overcome these drawbacks, various stimuli-sensitive DDSs were developed in the recent years. Key findings: Stimuli are a state of responsiveness to sensory stimulation or excitability. Stimuli sensitive systems are those systems which deal with the changes in the physiology of body with respective to the environment changes. These systems may be very beneficial for the controlled and sustained delivery of drug in the body if proper work would be carried out on these types of systems. Controlled drug delivery became the standard criteria in modern pharmaceutical product design and an intensive research is still going on in achieving much better drug product with features like effectiveness, reliability, and safety. Many changes like photo and light, temperature, pH, ion, glucose, and redox affect the release of drug from the delivery system. These stimuli-sensitive systems are used for various purposes in various forms like in parenteral, ocular, peroral, rectal, vaginal, nasal, dermal and transdermal drug delivery. Summary: Various literature surveys revealed that stimuli-sensitive DDSs can be explored as a potential tool for the delivery of a variety of macromolecules that are not effectively delivered by conventional techniques.

Keywords::

• glucose
• ocular
• redox
• stimuli
• transdermal

Acknowledgment

The authors are grateful to the ISF College of Pharmacy for providing all kinds of support and motivation to carry out this work.

Funding

This review received no specific grant from any funding agency in the public, commercial or not-for-profit sectors.

Declaration of interest

The authors report no declarations of interest. The authors alone are responsible for the content and writing of the paper.