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Abstract
The influence of polyethylene glycol (PEG) molar ratio on the nanoparticles (NPs) properties is described herein. Especially, a facile and nondestructive determination route has been raised to quantify the hemoglobin (Hb) amounts in NPs via an internal standard FTIR method. The subsequent results indicated that, briefly, the PEG molar ratio did negligible influence on the size distribution of NPs, however, it did have great effect on the NPs zeta potential and hydrophilicity as well as the Hb loading amount. These findings highlight that the PEG density on the surface is a key parameter affecting the NPs properties.
Acknowledgements
We sincerely thank the Shanghai Municipal Education Commission Special Research Fund for Excellent Young College and University Teachers (Grant No. yyy10004) and Shanghai City Board of education innovation project (Grant No. 12YZ162) for support of this work. Finally, we also acknowledge the financial supports from the Starting Research Fund from the Shanghai Institute of Technology, China(Grant No. YJ2009-32).
Declaration of interest
The authors report no conflicts of interest. The authors alone are responsible for the content and writing of the paper.
This project was supported by the National Natural Science Foundation of China (Grant No. 31100673) and the Shanghai Municipal Natural Science Foundation (Grant No. 11ZR1435800).