An update on clinical applications of electrospun nanofibers for skin bioengineering

Abstract

Mimicking morphological similarities of the natural extra cellular matrix (ECM), described by ultrafine continuous fibers, high surface to volume ratio, and high porosity is valuable for effective regeneration of injured skin tissue. Electrospun nanofibers, being one of the most favorable and fast developing products of technology today, display a tremendous potential in wound healing and skin tissue engineering. Under the remarkable attention being given to electrospun nanofibrous scaffolds in promoting wound healing and skin regeneration, this review focuses on the potential of the electrospinning technique as a promising tool for constructing polymeric nanofibrous scaffolds with the favorable physicochemical properties needed for skin bioengineering. In addition, current applications of electrospun nanofibrous matrices for skin bioengineering are detailed in this review.

Keywords::

• electrospinning
• extracellular matrix
• nanofibrous scaffold
• skin bioengineering

Authors’ contributions

NZ conceived of the study and participated in its design and coordination. AA participated in the sequence alignment and drafted the manuscript. All authors read and approved the final manuscript.

Acknowledgments

The authors thank the Department of Medical Biotechnology, Faculty of Advanced Medical Science of Tabriz University, for all support provided.

Declaration of interest

The authors have no declaration of interest. The authors alone are responsible for the content and writing of the paper.