RNA interference technology with emphasis on delivery vehicles—prospects and limitations

Abstract

Context: RNA interference (RNAi)-based therapeutics rely upon safe and efficient delivery of small interfering RNA (siRNA) molecules. Objective: This review explores various dimensions of RNAi with emphasis on the development of nanoparticle-based delivery vectors for safe and efficient siRNA delivery. Methods: An exhaustive database search has been done regarding studies done to investigate the potential of siRNA delivery employing nanoparticles has been cited in the present review. Results and conclusion: With the current challenges, there is a need for collaborative work allowing for the successful development of nanoparticle/siRNA complexes as health-promoting biotherapeutics.

Keywords::

• gene silencing
• nanoparticles
• RNA interference
• small interfering RNA
• transfection

Acknowledgements

This work was supported by Science & Engineering Research Board (SERB), Department of Science and Technology (SERC Fast Track Proposals for Young Scientists Scheme), and Government of India.

Declaration of interest

The authors report no declaration of interest. The authors alone are responsible for the content and writing of the paper.