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Abstract
This work examines the variation of longitudinal relaxation rate R1(= 1/T1) of the 19F-CF3-resonance of semifluorinated alkanes (SFAs) with oxygen tension (pO2), temperature (T) and pH in vitro. Contrary to their related perfluorocarbons (PFCs), SFA are amphiphilic and facilitate stable emulsions, a prerequisite for clinical use. A linear relationship between R1 and pO2 was confirmed for the observed SFAs at different temperatures. Using a standard saturation recovery sequence, T1 has been successfully measured using fluorine 19F-MRI with a self-constructed birdcage resonator at 9.4 T. A calibration curve to calculate pO2 depending on T and R1 was found for each SFA used. In contrast to the commonly used PFC, SFAs are less sensitive to changes in pO2, but more sensitive to changes in temperature. The influence of pH to R1 was found to be negligible.
Acknowledgements
We gratefully thank Novaliq GmbH, Heidelberg, Germany for supplies of all SFA samples examined.
Declaration of interest
This work was supported by the Federal Ministry of Education of Research (02NUK008F). The funders had no role in study design, data collection and analysis, decision to publish or preparation of the manuscript. The authors report no declarations of interest. The authors alone are responsible for the content and writing of the paper.