Development of PEGylated solid lipid nanoparticles of pentoxifylline for their beneficial pharmacological potential in pathological cardiac hypertrophy

Abstract

Objective: The present study was designed to develop PEGylated solid lipid nanoparticles (SLNs) of pentoxifylline (with increased t_½) for the management of cardiac hypertrophy. Materials and methods: PEGylated SLNs were prepared by melt emulsification method and characterised by zeta potential, polydispersity index, entrapment efficiency, in vitro release and pharmacokinetic profile. Hypertrophy was assessed as increase in tumour necrosis factor-alpha, mean arterial blood pressure, LV protein content and left ventricular end diastolic pressure. Result: PEGylated SLNs (F19) with increased t½ were developed and characterised. F19 attenuates hypertrophy assessed in terms of parameters employed. Conclusion: Thus, PEGylated SLNs (F19) of pentoxifylline have enhanced t_½ and consequently more significantly preclude cardiac hypertrophy as compared to pentoxifylline.

Keywords:

• cardiac remodelling
• circulation
• left ventricle
• nanoparticles
• PEGylation
• pentoxifylline

Acknowledgements

We express sincere thanks to Mr. Praveen Garg honourable chairman, ISF College of Pharmacy, Moga, Punjab, India, for providing needed facilities for the study.

Declaration of interest

The authors report no declarations of interest. The authors alone are responsible for the content and writing of the paper.