Curcumin nanoparticles attenuate cardiac remodeling due to pulmonary arterial hypertension

Kevin M. RiceCenter for Diagnostic Nanosystems, Marshall University, Huntington, WV, USA;School of Kinesiology, College of Health Professions, Marshall University, Huntington, WV, USA;Biotechnology Department, West Virginia State University, Institute, WV, USA;Department of Internal Medicine, Joan C. Edwards School of Medicine, Marshall University, Huntington, WV, USACorrespondence[email protected]

Nandini D. P. K. ManneCenter for Diagnostic Nanosystems, Marshall University, Huntington, WV, USA;Department of Public Health, College of Health Professions, Marshall University, Huntington, WV, USA

Madhukar B. KolliCenter for Diagnostic Nanosystems, Marshall University, Huntington, WV, USA;Department of Pharmacology, Physiology and Toxicology, Joan C. Edwards School of Medicine, Marshall University, Huntington, WV, USA

Paulette S. WehnerDepartment of Cardiology, Joan C. Edwards School of Medicine, Marshall University, Huntington, WV, USA

Lucy DornonDepartment of Cardiology, Joan C. Edwards School of Medicine, Marshall University, Huntington, WV, USA

Ravikumar ArvapalliCenter for Diagnostic Nanosystems, Marshall University, Huntington, WV, USA

Vellaisamy SelvarajCenter for Diagnostic Nanosystems, Marshall University, Huntington, WV, USA

Arun KumarDepartment of Clinical Laboratory Sciences, University of Delaware, Newark, DE, USA

Eric R. BloughCenter for Diagnostic Nanosystems, Marshall University, Huntington, WV, USA;School of Kinesiology, College of Health Professions, Marshall University, Huntington, WV, USA;Biotechnology Department, West Virginia State University, Institute, WV, USA;Department of Pharmacology, Physiology and Toxicology, Joan C. Edwards School of Medicine, Marshall University, Huntington, WV, USA;Department of Pharmaceutical Sciences and Research, Marshall University School of Pharmacy, Huntington, WV, USA

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Abstract

Herein, we investigate whether curcumin nanoparticles (Cur NPs) are effective for the treatment of monocrotaline (MCT)-induced pulmonary arterial hypertension in Sprague Dawley rat. Echocardiography was performed at the start of the study and 28 days after MCT injection. Compared to MCT only animals, Cur NP administration was associated with reduced right ventricular (RV) wall thickness and a decreased right ventricle weight/body weight ratio. Cur NPs also attenuated MCT induced increase in RV mRNA expression of TNF-α and IL-1β. These changes were also associated with decreased RV expression of nitrotyrosine, fibronectin and myosin heavy chain-β.

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Declaration of interest

This work was supported in part from DOE grant (DE-PS02-09ER-01 to E.R.B).

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Curcumin nanoparticles attenuate cardiac remodeling due to pulmonary arterial hypertension

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Curcumin nanoparticles attenuate cardiac remodeling due to pulmonary arterial hypertension

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