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Abstract
Wound healing is a complex process affected by several factors. In the present work, novel biocompatible PLGA–curcumin microparticle-embedded chitosan scaffold was fabricated for wound-healing application. Process variables involved in the preparation of microparticles were optimized using design of experiment. Scanning electron microscopy (SEM) confirmed the porous nature of scaffold with embedded microparticles. A maximum release of 14% of the encapsulated curcumin was observed at 12th hour. Modified tube dilution method showed that scaffold significantly (p < 0.05) reduced multiplication of Staphylococcus aureus. More than 50% of the excised wound in rats healed in 4 days with an epithilization period of 18 days.
Acknowledgements
The authors would like to acknowledge the authorities of Manipal University for providing the necessary facilities required for carrying out this experiment. Our thanks to Dr. Shaila Bhat, Professor and Head, Department of Pathology, Melaka Manipal Medical College, Manipal for histological interpretation.
Disclosure statement
The authors confirm that there are no known conflicts of interest associated with this publication.