Magnetic nanoparticles: preparation methods, applications in cancer diagnosis and cancer therapy

Saeid Shabestari KhiabaniFaculty of Medicine, Islamic Azad University Tabriz Branch, Tabriz, Iran;

Masoud FarshbafDepartment of Medical Nanotechnology, Faculty of Advanced Medical Sciences, Tabriz University of Medical Sciences, Tabriz, Iran; ;Student Research Committee, Tabriz University of Medical Sciences, Tabriz, Iran;

Abolfazl AkbarzadehFaculty of Medicine, Islamic Azad University Tabriz Branch, Tabriz, Iran; ;Department of Medical Nanotechnology, Faculty of Advanced Medical Sciences, Tabriz University of Medical Sciences, Tabriz, Iran; ;Drug Applied Research Center, Tabriz University of Medical Sciences, Tabriz, Iran

Soodabeh DavaranDepartment of Medical Nanotechnology, Faculty of Advanced Medical Sciences, Tabriz University of Medical Sciences, Tabriz, Iran; ;Drug Applied Research Center, Tabriz University of Medical Sciences, Tabriz, IranCorrespondence[email protected]

Abstract

Super-paramagnetic iron oxide nanoparticles (SPIONs) have been widely explored as novel magnetic resonance imaging (MRI) contrast agents because of a combination of favorable super-paramagnetic properties, biodegradability, and surface properties. Among the numerous MNPs under examination, SPIONs have involved considerable interest due to their outstanding magnetic properties, biocompatibility, and biodegradability. This review debates the ABCs of MR imaging, reports and informs the state of the art of magnetic nanoparticles in cancer dealing the source of SPIONs’ exclusive magnetic properties, recent progresses in MRI acquisition methods for detection of SPIONs.

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The authors declare that they have no competing interests.

Funding information

This work is funded by 2016 Drug Research Center, Tabriz University of Medical Sciences Grant.

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